Dale J Kempf : rechercher sur Z-Library

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1

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Kempf, Dale J., Sham, Hing L., Marsh, Kennan C., Flentge, Charles A., Betebenner, David, Green, Brian E., McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E., Kati, Warren M.,

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 189 KB

english, 1998

2

Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)

Hing L Sham, David A Betebenner, Thomas Herrin, Gondi Kumar, Ayda Saldivar, Sudthida Vasavanonda, Akhter Molla, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 127 KB

english, 2001

3

Synthesis and structure–activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

Hing L. Sham, David A. Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 89 KB

english, 2002

4

ChemInform Abstract: Synthesis and Structure—Activity Relationships of a Novel Series of HIV-1 Protease Inhibitors Encompassing ABT-378 (Lopinavir).

Hing L. Sham, David A. Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 32 KB

english, 2002

5

Enantioselective Synthesis of Antiinfluenza Compound A-315675 (I).

David A. DeGoey, Hui-Ju Chen, William J. Flosi, David J. Grampovnik, Clinton M. Yeung, Larry L. Klein, Dale J. Kempf

Journal:

Année:

2002

Fichier:

PDF, 27 KB

2002

6

Novel Lopinavir Analogues Incorporating Non-aromatic P-1 Side Chains — Synthesis and Structure—Activity Relationships.

Hing L. Sham, Chen Zhao, Leping Li, David A. Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Année:

2003

Fichier:

PDF, 147 KB

2003

7

Design, Synthesis, and Neuraminidase Inhibitory Activity of GS-4071 Analogues that Utilize a Novel Hydrophobic Paradigm.

Stephen Hanessian, Jianchio Wang, Debra Montgomery, Vincent Stoll, Kent D. Steward, Warren Kati, Clarence Maring, Dale Kempf, Charles Hutchins, W. Graeme Laver

Journal:

Année:

2003

Fichier:

PDF, 147 KB

2003

8

Synthesis and Antiviral Activity of P1′ Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors.

Peggy P. Huang, John T. Randolph, Larry L. Klein, Sudthida Vasavanonda, Tatyana Dekhtyar, Vincent S. Stoll, Dale J. Kempf

Journal:

Année:

2004

Fichier:

PDF, 23 KB

2004

9

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor

John T. Randolph, Xiaolin Zhang, Peggy P. Huang, Larry L. Klein, Kevin A. Kurtz, Alex K. Konstantinidis, Wenping He, Warren M. Kati, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 436 KB

english, 2008

10

Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease

Dale J. Kempf, Charles A. Flentge, Norman E. Wideburg, Ayda Saldivar, Sudthida Vasavanonda, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 225 KB

english, 1995

11

Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV

William J. Flosi, David A. DeGoey, David J. Grampovnik, Hui-ju Chen, Larry L. Klein, Tatyana Dekhtyar, Sherie Masse, Kennan C. Marsh, Hong Mei Mo, Dale Kempf

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 312 KB

english, 2006

12

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands

Xiaoqi Chen, Dale J. Kempf, Lin Li, Hing L. Sham, Sudthida Vasavanonda, Norman E. Wideburg, Ayda Saldivar, Kennan C. Marsh, Edith McDonald, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 176 KB

english, 2003

13

Corrigendum to “Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)”: [Bioorg. Med. Chem. Lett. 11 (2001) 1351]

Hing L. Sham, David A. Betebenner, Thomas Herrin, Gondi Kumar, Ayda Saldivar, Sudthida Vasavanonda, Akhter Molla, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Fichier:

PDF, 204 KB

2004

14

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Clarence J. Maring, Dale J. Kempf, Warren M. Kati, Vincent Stoll, Kent D. Stewart, Graeme Laver

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 308 KB

english, 2005

15

Oximinoarylsulfonamides as potent HIV protease inhibitors

Clinton M. Yeung, Larry L. Klein, Charles A. Flentge, John T. Randolph, Chen Zhao, MingHua Sun, Tatyana Dekhtyar, Vincent S. Stoll, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 185 KB

english, 2005

16

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

A. Chris Krueger, Yibo Xu, Warren M. Kati, Dale J. Kempf, Clarence J. Maring, Keith F. McDaniel, Akhteruzzaman Molla, Debra Montgomery, William E. Kohlbrenner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 135 KB

english, 2008

17

Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Pamela L. Donner, Qinghua Xie, John K. Pratt, Clarence J. Maring, Warren Kati, Wen Jiang, Yaya Liu, Gennadiy Koev, Sherie Masse, Debra Montgomery, Akhter Molla, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 185 KB

english, 2008

18

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs

Charles A. Flentge, John T. Randolph, Peggy P. Huang, Larry L. Klein, Kennan C. Marsh, John E. Harlan, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 345 KB

english, 2009

19

An `Inside-the-Box' Approach to Drug Resistance

Kent D. Stewart, Dale J. Kempf

Journal:

Chemistry & Biology

Année:

2004

Langue:

english

Fichier:

PDF, 36 KB

english, 2004

20

Stereochemical studies of lasalocid aldol epimers. Assignments and interconversions.

W.Clark Still, Dale Kempf, Peter Hauck

Journal:

Tetrahedron Letters

Année:

1986

Langue:

english

Fichier:

PDF, 153 KB

english, 1986

21

Remote lithiation of N-methallyl amides

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 251 KB

english, 1989

22

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm

Stephen Hanessian, Jianchio Wang, Debra Montgomery, Vincent Stoll, Kent D. Stewart, Warren Kati, Clarence Maring, Dale Kempf, Charles Hutchins, W.Graeme Laver

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 189 KB

english, 2002

23

Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors

Xiaoqi Chen, Lin Li, Dale J. Kempf, Hing Sham, Norman E. Wideburg, Ayda Saldivar, Sudthida Vasavanonda, Kennan C. Marsh, Edith McDonald, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 313 KB

english, 1996

24

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease

Dale J. Kempf, Akhteruzzaman Molla, Kennan C. Marsh, Chang Park, A.David Rodrigues, Marina Korneyeva, Sudthida Vasavanonda, Edith McDonald, Charles A. Flentge, Steven Muchmore, Norman E. Wideburg, Ayd

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 305 KB

english, 1997

25

Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands

Xiaoqi Chen, Dale J. Kempf, Hing L. Sham, Brian E. Green, Akhteruzaman Molla, Marina Korneyeva, Sudthida Vasavanonda, Norman E. Wideburg, Ayda Saldivar, Kennan C. Marsh, Edith McDonald, Daniel W. Norb

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 327 KB

english, 1998

26

Design of orally bioavailable, symmetry-based inhibitors of HIV protease

Dale J. Kempf, Kennan C. Marsh, Lynnmarie Codacovi Fino, Pamela Bryant, Adrienne Craig-Kennard, Hing L. Sham, Chen Zhao, Sudthida Vasavanonda, William E. Kohlbrenner, Norman E. Wideburg, Ayda Saldivar

Journal:

Bioorganic & Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.51 MB

english, 1994

27

X-ray crystallographic structure of ABT-378 (Lopinavir) bound to HIV-1 protease

Vincent Stoll, Wenying Qin, Kent D. Stewart, Clarissa Jakob, Chang Park, K. Walter, R.L. Simmer, Rosalind Helfrich, Dirk Bussiere, J. Kao, Dale Kempf, Hing L. Sham, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 246 KB

english, 2002

28

Progress in the discovery of orally bioavailable inhibitors of HIV protease

Journal:

Perspectives in Drug Discovery and Design

Année:

1995

Langue:

english

Fichier:

PDF, 618 KB

english, 1995

29

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia

Jeffrey F. Waring, Rita Ciurlionis, Kennan Marsh, Larry L. Klein, David A. DeGoey, John T. Randolph, Brian Spear, Dale J. Kempf

Journal:

Archives of Toxicology

Année:

2010

Langue:

english

Fichier:

PDF, 635 KB

english, 2010

30

Highly efficient synthesis of 2(S)-3(R,S)-2-amino-4,4-difluoro-1,6-diphenyl-3-hydroxyhexane — the key intermediate for a series of potent HIV proteinase inhibitors

Hing L. Sham, David A. Betebenner, Norman E. Wideburg, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Journal of Fluorine Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 332 KB

english, 1995

31

Synthesis and antiviral activity of P1′ arylsulfonamide azacyclic urea HIV protease inhibitors

Peggy P Huang, John T Randolph, Larry L Klein, Sudthida Vasavanonda, Tatyana Dekhtyar, Vincent S Stoll, Dale J Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 321 KB

english, 2004

32

Stereochemical studies of lasalocid epimers. Ion-driven epimerizations.

W.Clark Still, Peter Hauck, Dale Kempf

Journal:

Tetrahedron Letters

Année:

1987

Langue:

english

Fichier:

PDF, 241 KB

english, 1987

33

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships

Hing L Sham, Chen Zhao, Leping Li, David A Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 98 KB

english, 2002

34

Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans

Gondi N. Kumar, Venkata K. Jayanti, Marianne K. Johnson, John Uchic, Samuel Thomas, Ronald D. Lee, Brian A. Grabowski, Hing L. Sham, Dale J. Kempf, Jon F. Denissen, Kennan C. Marsh, Eugene Sun, Stanle

Journal:

Pharmaceutical Research

Année:

2004

Langue:

english

Fichier:

PDF, 121 KB

english, 2004

35

Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane: the core unit of a potent HIV proteinase inhibitor

Sham, Hing L., Wideburg, Norman E., Spanton, Stephen G., Kohlbrenner, William E., Betebenner, David. A., Kempf, Dale J., Norbeck, Daniel W., Plattner, Jacob J., Erickson, John W.

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1991

Langue:

english

Fichier:

PDF, 222 KB

english, 1991

36

Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol

Kempf, Dale J., Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E., Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., Bryant, Pamela

Journal:

Journal of Medicinal Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 1.46 MB

english, 1993

37

Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats

Yi Yang, Annette J. Dahly-Vernon, Eric A.G. Blomme, Jie Lai-Zhang, Dale J. Kempf, Kennan C. Marsh, Yvette A. Harrington, Steven H. Nye, Darin L. Evans, Richard J. Roman, Howard J. Jacob, Jeffrey F. Wa

Journal:

The Veterinary Journal

Année:

2010

Langue:

english

Fichier:

PDF, 769 KB

english, 2010

38

Characterization of resistant HIV variants generated by in vitro passage with lopinavir/ritonavir

Hongmei Mo, Liangjun Lu, Tatyana Dekhtyar, Kent D. Stewart, Eugene Sun, Dale J. Kempf, Akhteruzzaman Molla

Journal:

Antiviral Research

Année:

2003

Langue:

english

Fichier:

PDF, 247 KB

english, 2003

39

Recent developments in HIV protease inhibitor therapy

Akhteruzzaman Molla, G Richard Granneman, Eugene Sun, Dale J Kempf

Journal:

Antiviral Research

Année:

1998

Langue:

english

Fichier:

PDF, 299 KB

english, 1998

40

Stereocontrolled synthesis of Ψ[CH=CH] dipeptide isosteres

DALE J. KEMPF, XIU CHUN WANG, STEPHEN G. SPANTON

Journal:

Chemical Biology & Drug Design

Année:

1991

Langue:

english

Fichier:

PDF, 477 KB

english, 1991

41

Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease

Hosur, Madhusoodan V., Bhat, T. Narayana, Kempf, Dale J., Baldwin, Eric T., Liu, Beishan, Gulnik, Sergei, Wideburg, Norman E., Norbeck, Daniel W., Appelt, Krzysztof, Erickson, John W.

Journal:

Journal of the American Chemical Society

Année:

1994

Langue:

english

Fichier:

PDF, 4.14 MB

english, 1994

42

Potent HIV-1 protease inhibitors with antiviral activities in vitro

Hing L. Sham, David A. Betebenner, Norman E. Wideburg, Ayda C. Saldivar, William E. Kohlbrenner, Sudthida Vasavanonda, Dale J. Kempf, Daniel W. Norbeck, Chen Zhao, Jacob J. Clement, John E. Erickson,

Journal:

Biochemical and Biophysical Research Communications

Année:

1991

Langue:

english

Fichier:

PDF, 373 KB

english, 1991

43

Pseudo-symmetrical difluoroketones: Highly potent and specific inhibitors of HIV-1 protease

Hing L. Sham, David A. Betebenner, Norman Wideburg, Ayda C. Saldivar, William E. Kohlbrenner, Adrienne Craig-Kennard, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Clement, John E. Erickson, Jacob J.

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 380 KB

english, 1993

44

Sequence and Phenotypic Analysis for Resistance Monitoring in Hepatitis C Virus Drug Development: Recommendations From the HCV DRAG

Ann D. Kwong, Isabel Najera, Jill Bechtel, Scott Bowden, Joseph Fitzgibbon, Patrick Harrington, Dale Kempf, Tara L. Kieffer, Diana Koletzki, George Kukolj, Sharlene Lim, Tami Pilot–Matias, Kai Lin, Ni

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 5.55 MB

english, 2011

45

A Rapid Fluorogenic Assay of HIV Protease Inhibitors

EDMUND MATAYOSHI, GARY WANG, GRANT KRAFFT, DALE KEMPF, LYNN CODACOVI, JOHN ERICKSON

Journal:

Annals of the New York Academy of Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 135 KB

english, 1990

46

Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores

Wang, Gary T., Li, Sam, Wideburg, Norman, Krafft, Grant A., Kempf, Dale J.

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1995

47

Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors

Kempf, Dale J., Sowin, Thomas J., Doherty, Elizabeth M., Hannick, Steven M., Codavoci, LynnMarie, Henry, Rodger F., Green, Brian E., Spanton, Stephen G., Norbeck, Daniel W.

Journal:

Journal of Organic Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1992

48

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Hajduk, Philip J., Dinges, Jürgen, Miknis, Gregory F., Merlock, Megan, Middleton, Tim, Kempf, Dale J., Egan, David A., Walter, Karl A., Robins, Terry S., Shuker, Suzy B., Holzman, Thomas F., Fesik, St

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 272 KB

english, 1997

49

P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses

DeGoey, David A., Grampovnik, David J., Chen, Hui-Ju, Flosi, William J., Klein, Larry L., Dekhtyar, Tatyana, Stoll, Vincent, Mamo, Mulugeta, Molla, Akhteruzzaman, Kempf, Dale J.

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.68 MB

english, 2011

50

Synthesis of rigid, heterocyclic dipeptide analogs

Kempf, Dale J., Condon, Stephen L.

Journal:

Journal of Organic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 742 KB

english, 1990